A 49-year-old female patient was referred to our retina clinic because of a peripapillary vascular tumor detected during a routine eye examination. The fundus examination showed peripapillary grape-like clusters of dilated sac-like aneurysms filled with dark red blood (Figure 1A). Fundus fluorescein angiography revealed typical blood levels. There was plasma-erythrocytic separation was observed within some aneurysms because of pooling of the dye in the superior plasma (producing hyperfluorescence) and inferior sedimented red blood cells (producing hypofluorescence) (Figure 1B). Spectral-domain optical coherence tomography passing through the lesion showed grape-like bunches of hyporeflective vesicular formations surrounded by a ring with a hyperreflective edge involving the inner retinal layers (Figure 1C).

Cavernous hemangiomas of the retina may follow the courses of major veins or manifest in the peripapillary area with aneurysmal venules dilation. They may co-occur with cutaneous or central nervous system hemangiomas⁽¹⁾. They can be diagnosed using imaging results in combination with the distinctive appearance of the fundus⁽¹⁾

ACKNOWLEDGMENT

The authors would like to thank Enago (www.enago.br) for the English editing.

REFERENCE

1. Wang W, Chen L. Cavernous hemangioma of the retina: a comprehensive review of the literature (1934-2015). Retina. 2017; 37(6):611-21.

AUTHORS' CONTRIBUTIONS

Significant contribution to conception and design: Kemal Tekin, Mehmet Yasin Teke. Data acquisition: Kemal Tekin, Mehmet Yasin Teke. Data analysis and interpretation: not applicable. Manuscript drafting: Kemal Tekin. Significant intellectual content revision of the manuscript: Kemal Tekin, Mehmet Yasin Teke. Final approval of the submitted manuscript: Kemal Tekin, Mehmet Yasin Teke. Statistical analysis: not applicable. Obtaining funding: not applicable. Supervision of administrative, technical, or material support: not applicable. Research group leadership: not applicable.

Informed consent was obtained from the patient included in this study.

Submitted for publication: August 19, 2024.
Accepted for publication: September 11, 2024.

Funding: This study received no specific financial support.

Disclosure of potential conflicts of interest: The authors declare no potential conflicts of interest.