Dear Editor:

We would like to share ideas on “TXNRD2 (rs35934224) CT genotype as a possible protective marker for primary open-angle glaucoma in a Brazilian population⁽¹⁾.” Tenório et al. concluded that “Our data suggest an association between TXNRD2 gene polymorphism (rs35934224) with primary open-angle...”⁽¹⁾. We agree that TXNRD2 (rs35934224) CT genotype might or might not be associated with primary open-angle glaucoma. It is also necessary to recognize the effects of possible confounding factors. It is necessary to realize the possible effect of other genetic polymorphisms that might be associated with primary open-angle glaucoma, although there is a control group in this report. Examples of those genetic polymorphisms comprise CYP1B1 gene polymorphisms and variants in MT-CYB and MT-ND4 genes^(2,3).

REFERENCES

1. Tenório AL, Lira RP, do Carmo RF, Galvão Filho RP, Falção Neto PT, Vaz RT, et al. TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population. Arq Bras Oftalmol. 2021;S0004-27492021005005222. Epub ahead of print.

2. Calero-Dueñas N, Mateos-Olivares M, Ussa F, Juberías JR, Marcos M, Pastor-Idoate S, et al. Polymorphisms in CYP1B1 gene and the risk of suffering primary open-angle glaucoma: systematic review and meta-analysis. Eur J Ophthalmol. 2022:11206721221077621. Epub ahead of print.

3. Lo Faro V, Nolte IM, Ten Brink JB, Snieder H, Jansonius NM, Bergen AA. Mitochondrial genome study identifies association between primary open-angle glaucoma and variants in MT-CYB, MT-ND4 genes and haplogroups. Front Genet [Internet]. 2021 [cited 2022 Jan 21];12:781189.Available from: Frontiers | Mitochondrial Genome Study Identifies Association Between Primary Open-Angle Glaucoma and Variants in MT-CYB, MT-ND4 Genes and Haplogroups | Genetics (frontiersin.org)

Submitted for publication: March 3, 2022.
Accepted for publication: March 14, 2022.

Funding: This study received no specific financial support

Disclosure of potential conflicts of interest: None of the authors have any potential conflicts of interest to disclose