Sir, the article on "plagiarism and misconduct in research"(1) is very interesting. Chamon reported the use of the computational tool for help detect the plagiarism(1). In fact, the detection of plagiarism in submitted manuscript should be the requirement for all biomedical journals. The pre-submission screening should be encouraged for all contributors(2). Of interest, although there are several attempts the problems can still be detected. The use of computational tool might be a solution but it still has the limitations. First, the computational program might not be possible to detect the problem of figure plagiarism as well as conceptual plagiarism(3), which are also common problems in the present day. Second, when the problem is detected and reported, the response and action from the plagiarist's institute might not appropriate(4). As Chamon mentioned for "where we are and what we can do"(1), it seems that it is still a long way to successfully manage the problem. Re-evaluation on the success of the implementation of the computation tool for detection of plagiarism should be continuously done.