ABSTRACT

PURPOSE: To evaluate the differences of wavefront aberrations under cycloplegic, scotopic and photopic conditions. METHODS: A total of 174 eyes of 105 patients were measured using the wavefront sensor (WaveScan® 3.62) under different pupil conditions: cycloplegic 8.58 ± 0.54 mm (6.4 mm - 9.5 mm), scotopic 7.53 ± 0.69 mm (5.7 mm - 9.1 mm) and photopic 6.08 ± 1.14 mm (4.1 mm - 8.8 mm). The pupil diameter, standard Zernike coefficients, root mean square of higher-order aberrations and dominant aberrations were compared between cycloplegic and scotopic conditions, and between scotopic and photopic conditions. RESULTS: The pupil diameter was 7.53 ± 0.69 mm under the scotopic condition, which reached the requirement of about 6.5 mm optical zone design in the wavefront-guided surgery and prevented measurement error due to the pupil centroid shift caused by mydriatics. Pharmacological pupil dilation induced increase of standard Zernike coefficients Z3-3, Z4(0) and Z5-5. The higher-order aberrations, third-order aberration, fourth-order aberration, fifth-order aberration, sixth-order aberration, and spherical aberration increased statistically significantly, compared to the scotopic condition (P<0.010). When the scotopic condition shifted to the photopic condition, the standard Zernike coefficients Z4(0), Z4², Z6-4, Z6-2, Z6² decreased and all the higher-order aberrations decreased statistically significantly (P<0.010), demonstrating that accommodative miosis can significantly improve vision under the photopic condition. Under the three conditions, the vertical coma aberration appears the most frequently within the dominant aberrations without significant effect by pupil size variance, and the proportion of spherical aberrations decreased with the decrease of the pupil size. CONCLUSIONS: The wavefront aberrations are significantly different under cycloplegic, scotopic and photopic conditions. Using the wavefront sensor (VISX WaveScan) to measure scotopic wavefront aberrations is feasible for the wavefront-guided refractive surgery.

Keywords: Accommodation, ocular; Mydriatics; Cornea; Diagnostic techniques, ophthalmological; Refractive errors; Corneal wavefront aberration; Refraction ocular; Pupil

RESUMO

OBJETIVO: Avaliar as diferenças de aberrações de frente de onda, em diferentes condições pupilares: sob cicloplegia, escotópica e fotópica. MÉTODOS: Um total de 174 olhos de 105 pacientes foram avaliados utilizando o sensor de frente de onda (WaveScan® 3.62) em diferentes condições pupilares: sob cicloplegia 8,58 ± 0,54 mm (6.4 mm-9.5 mm), escotópica 7,53 ± 0,69 mm (5,7 mm - 9,1 mm) e fotópica 6,08 ± 1,14 mm (4,1 mm - 8,8 mm). Diâmetro da pupila, coeficientes de Zernike, RMS ("Root Mean Square") das aberrações de alta ordem e as aberrações dominantes foram comparados entre as condições sob cicloplegia e escotópica, e entre as condições escotópica e fotópica. RESULTADOS: O diâmetro da pupila foi 7,53 ± 0.69 mm sob a condição escotópica e atingiu a exigência de cerca de 6,5 mm de zona óptica na cirurgia baseada em análise de frentes de ondas, evitando erros de medição consequentes à mudança de centroide pupilar provocada por midriáticos. A dilatação farmacológica da pupila induziu aumento dos coeficientes de Zernike Z3-3, Z4(0) e Z5-5. As aberrações de mais alta ordem (terceira, quarta, quinta e sexta ordem) e a aberração esférica aumentaram de forma estatisticamente significativa, em comparação com a condição escotópica (P<0,010). Quando a condição escotópica se mudou para a condição fotópica, os coeficientes de Zernike Z4(0), Z4², Z6-4, Z6-2, Z6² e todas as aberrações de alta ordem diminuíram de forma estatisticamente significativa (P<0,010), demonstrando que a miose acomodativa pode significativamente melhorar a visão sob a condição fotópica. Sob as três condições, a aberração coma vertical apareceu mais frequentemente dentro das aberrações dominantes, sem influência significativa da variação do tamanho da pupila, e a proporção de aberração esférica diminuiu com a diminuição do tamanho da pupila. CONCLUSÕES: As aberrações de frente de onda são significativamente diferentes sob cicloplegia, condições escotópica e fotópica. O uso do sensor de frentes de onda (VISX WaveScan) para medir as aberrações de frente de onda escotópicas é uma opção viável para a cirurgia refrativa baseada em análise de frentes de onda.

Descritores: Acomodação ocular; Midriáticos; Córnea; Técnicas de diagnóstico oftalmológico; Erros de refração; Aberrações de frente de onda da córnea; Refração ocular; Pupila

ORIGINAL ARTICLE ARTIGO ORIGINAL

 

Comparison of wavefront aberrations under cycloplegic, scotopic and photopic conditions using WaveScan

 

Comparação de aberrações de frente de onda sob cicloplegia, condições escotópica e fotópica usando WaveScan

 

 

Rong Fan^I; Tao He^II; Yan Qiu^II; Yu-Lan Di^II; Su-yun Xu^II; Yao-yu Li^II

^IDepartment of Ophthalmology, China Meitan General Hospital
^IIDepartment of Ophthalmology, General Hospital of Beijing

Correspondence address

 

 

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ABSTRACT

PURPOSE: To evaluate the differences of wavefront aberrations under cycloplegic, scotopic and photopic conditions.
METHODS: A total of 174 eyes of 105 patients were measured using the wavefront sensor (WaveScan^® 3.62) under different pupil conditions: cycloplegic 8.58 ± 0.54 mm (6.4 mm - 9.5 mm), scotopic 7.53 ± 0.69 mm (5.7 mm - 9.1 mm) and photopic 6.08 ± 1.14 mm (4.1 mm - 8.8 mm). The pupil diameter, standard Zernike coefficients, root mean square of higher-order aberrations and dominant aberrations were compared between cycloplegic and scotopic conditions, and between scotopic and photopic conditions.
RESULTS: The pupil diameter was 7.53 ± 0.69 mm under the scotopic condition, which reached the requirement of about 6.5 mm optical zone design in the wavefront-guided surgery and prevented measurement error due to the pupil centroid shift caused by mydriatics. Pharmacological pupil dilation induced increase of standard Zernike coefficients Z₃^-3, Z₄⁰ and Z₅^-5. The higher-order aberrations, third-order aberration, fourth-order aberration, fifth-order aberration, sixth-order aberration, and spherical aberration increased statistically significantly, compared to the scotopic condition (P<0.010). When the scotopic condition shifted to the photopic condition, the standard Zernike coefficients Z₄⁰, Z₄², Z₆^-4, Z₆^-2, Z₆² decreased and all the higher-order aberrations decreased statistically significantly (P<0.010), demonstrating that accommodative miosis can significantly improve vision under the photopic condition. Under the three conditions, the vertical coma aberration appears the most frequently within the dominant aberrations without significant effect by pupil size variance, and the proportion of spherical aberrations decreased with the decrease of the pupil size.
CONCLUSIONS: The wavefront aberrations are significantly different under cycloplegic, scotopic and photopic conditions. Using the wavefront sensor (VISX WaveScan) to measure scotopic wavefront aberrations is feasible for the wavefront-guided refractive surgery.

Keywords: Accommodation, ocular/physiology; Mydriatics/administration & dosage; Cornea/physiopathology; Diagnostic techniques, ophthalmological; Refractive errors; Corneal wavefront aberration; Refraction ocular; Pupil/physiology

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RESUMO

OBJETIVO: Avaliar as diferenças de aberrações de frente de onda, em diferentes condições pupilares: sob cicloplegia, escotópica e fotópica.
MÉTODOS: Um total de 174 olhos de 105 pacientes foram avaliados utilizando o sensor de frente de onda (WaveScan^® 3.62) em diferentes condições pupilares: sob cicloplegia 8,58 ± 0,54 mm (6.4 mm-9.5 mm), escotópica 7,53 ± 0,69 mm (5,7 mm - 9,1 mm) e fotópica 6,08 ± 1,14 mm (4,1 mm - 8,8 mm). Diâmetro da pupila, coeficientes de Zernike, RMS ("Root Mean Square") das aberrações de alta ordem e as aberrações dominantes foram comparados entre as condições sob cicloplegia e escotópica, e entre as condições escotópica e fotópica.
RESULTADOS: O diâmetro da pupila foi 7,53 ± 0.69 mm sob a condição escotópica e atingiu a exigência de cerca de 6,5 mm de zona óptica na cirurgia baseada em
análise de frentes de ondas, evitando erros de medição consequentes à mudança de centroide pupilar provocada por midriáticos. A dilatação farmacológica da pupila induziu aumento dos coeficientes de Zernike Z₃^-3, Z₄⁰ e Z₅^-5. As aberrações de mais alta ordem (terceira, quarta, quinta e sexta ordem) e a aberração esférica aumentaram de forma estatisticamente significativa, em comparação com a condição escotópica (P<0,010). Quando a condição escotópica se mudou para a condição fotópica, os coeficientes de Zernike Z₄⁰, Z₄², Z₆^-4, Z₆^-2, Z₆² e todas as aberrações de alta ordem diminuíram de forma estatisticamente significativa (P<0,010), demonstrando que a miose acomodativa pode significativamente melhorar a visão sob a condição fotópica. Sob as três condições, a aberração coma vertical apareceu mais frequentemente dentro das aberrações dominantes, sem influência significativa da variação do tamanho da pupila, e a proporção de aberração esférica diminuiu com a diminuição do tamanho da pupila.
CONCLUSÕES: As aberrações de frente de onda são significativamente diferentes sob cicloplegia, condições escotópica e fotópica. O uso do sensor de frentes de onda (VISX WaveScan) para medir as aberrações de frente de onda escotópicas é uma opção viável para a cirurgia refrativa baseada em análise de frentes de onda.

Descritores: Acomodação ocular/fisiologia; Midriáticos/administração & dosagem; Córnea/fisiopatologia; Técnicas de diagnóstico oftalmológico; Erros de refração; Aberrações de frente de onda da córnea; Refração ocular; Pupila/fisiologia

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INTRODUCTION

Refractive surgery aims to ultimately regain favorable vision quality in myopia patients. The vision quality including the eye refraction medium, the optic nerve, and mental factors especially relates to the measurement of aberrations. The wavefront-guided refractive surgery is an effective method to achieve the aim, accounting for 67% to 91% of all refractive surgeries from 2003 to 2009^(1,2). A suitable customized wavefront correction might be one that minimizes aberrations with an eye's natural pupil and its natural accommodative posture when viewing a distant object⁽³⁾. Using the self adapting optical system, the optic nerve was found to change in lower-order aberrations and higher-order aberrations⁽⁴⁾. When the refractive surgery or the contact lens changed the original aberration model, the visual cortex compensation recovered the original aberrations model, completely changing the time for aberrations and determining interests for patients. Thus in the refractive surgery, under-correction and over-correction of aberrations, or change of previous aberrations lead to difficulty in postoperative aberration adaption, and possibly even vision complaints in some patients. So, it is very important to measure preoperative aberration in a feasible condition.

Currently, in different wavefront analysis systems and different Zernike polynomials^(2,5-8), there are two different measurements: with pupil dilation^(3,7,9-12) or without pupil dilation^(2,12-15), and there are also differences in patients' age, refraction conditions, sampling and statistical analysis, so no gold standard exists for wavefront devices^(5,6). There are two kinds of high order aberration detection: under cycloplegic conditions with pharmacological pupil dilation and under scotopic conditions with natural pupil dilation in a darkroom. Some studies show that pharmacological pupil dilation leads to uneven my-driasis, pupil centroid shift and eccentricity, causing change of different degrees to the higher-order aberrations^(9,16-18). Further studies are still re-quired to investigate whether the difference in aberrations under cycloplegic and scotopic conditions exists and whether the aberrations under scotopic conditions match the natural condition of the eye. VISX S4 system (VISX USA, Inc., SantA Clara, CA) can measure aberrations over a 6-mm pupil diameter. We used the wavefront sensor (VISX WaveScan 3.62) to measure scotopic wavefront aberrations in young patients and compared them with data under cycloplegic and photopic conditions. This study evaluated the applicability of scotopic wavefront aberrations and intended to find out a feasible examining condition to get the whole information of high order aberrations accurately before surgery, so doctors can design an optimal ablation protocol in the wavefront-guided refractive surgery.

 

METHODS

SUBJECTS

The subjects were enrolled from patients with myopia and myopic astigmatism who were candidates for wavefront-guided LASIK in the Excimer Laser Center, Military General Hospital of Beijing People's Liberation Army (Beijing, China) from January 10^th, 2010 to March 10^th, 2010. After approval from the Institutional Review Board for Human Research at the Military General Hospital of Beijing People's Liberation Army, all subjects signed an appropriate informed consent. Patients with a series of examination, including optometry, retinophotoscopy, corneal topography, corneal thickness, and intraocular pressure were enrolled. Inclusion criteria: All subjects were required to have stable refraction for at least to 2 years, discontinuation of contact lens use for at least 2 weeks and with best corrected visual acuity >20/20. Exclusion criteria: Patients with a history of eye surgery, trauma, ocular surface diseases or intraocular diseases were excluded. Initially, a total of 125 patients (224 eyes) were included. Of them, 32 eyes were excluded because the pupil diameter did not meet the requirements for quantification under cycloplegic and photopic conditions and 18 excluded due to discontinuation of study. Ultimately, 174 (left, 85; right, 89) eyes from 105 patients (male, 48; female, 57) were enrolled.

INSTRUMENTS

The wavefront sensor (WaveScan 3.62) was purchased from AMO (Santa Clara, California, US). This instrument uses the Hartmann-Shack system of aberrometry for scotopic examination. WaveScan expresses results as Zernike polynomial coefficients up to and including the sixth order. The observation target is a very narrow spot red light source (0.02 Lux). The tunnel vision approach was considered for measurement, and the eye accommodation was relaxed with an automatic precompensation of +8.00 D during examination⁽¹⁹⁾. The system was adjusted every day when it was started. The examination procedure and data inclusion criteria for the three conditions were identical. Data inclusion criteria were as follows: the stability of four images with lower-order data and higher-order data were candidates. The images coincided with the pupil center, the corneal apex and iris center, clear iris, complete and clear Hartmann-Shack dot arrays were chosen. The pupil diameter was recorded under cycloplegic, scotopic and photopic conditions and the higher-order aberrations were extracted for quantification when the pupil diameter was 6 mm.

METHODS

The eyes were measured by the same wavefront sensor in terms of the wavefront aberrations (lower-order aberrations and higher-order aberrations) and the pupil diameter. Eye drops were stopped during measurements. In this study, the brightness of the environment light was <1 Lux for pharmacological and scotopic pupil dilations. According to the International Commission on Illumination, the lighting systems in the night including the roadway lighting and vehicle lighting have a higher brightness (>1-2 Lux). In the present study, illumination was lower than actual illumination at night, so it can simulate the night environment. Rapid mydriatics was a complex formula of tropicamide (Mydrin, 10 ml, containing tropicamide 50 mg plus phenylephrine hydrochloride 50 mg) (Santen Pharmaceutical Co., Shiga, Japan). Dates were obtained under three conditions. 1) For wavefront aberrations under the photopic condition, natural pupils were measured under the natural light in room with brightness of 280 Lux (modelBM-7A; TOPCON, Japan 2) For wavefront aberrations under the scotopic condition, natural pupils were measured after the patients adapted to the dark room for 10 min. 3) For wavefront aberrations under the cycloplegic condition, one drop of composite tropicamide was dropped in the examined eye and another drop was dropped after 10 min if necessary. In order to prevent increased lenticular accommodation during consecutive measurements, an interval of 20 min was required for examination between the photopic and scotopic conditions. The measurements were conducted within 2 d.

STATISTICAL ANALYSIS

SPSS (version 13.0) (SPSS Inc, Chicago, IL, USA) was used. The pupil diameter, standard Zernike coefficients, root mean square (RMS) of higher-order aberrations and dominant aberrations were compared between cycloplegic and scotopic conditions, and between scotopic and photopic conditions. For measurement differences with normal distribution, paired t-test was used for comparison; for measurement differences with abnormal distribution, Wilcoxon signed ranks test was used for comparison. A statistically significant difference was considered if P was <0.010.

 

RESULTS

Patients' age ranged from 18 to 30 years, with a mean age of 22 years. They had spherical power of -5.53 ± 2.00 D (-0.14 D-10.56 D), and cylindrical power of -0.95 ± 0.77 D (-0.40 D-3.68 D). The pupil diameter was 8.58 ± 0.54 mm (6.4 mm-9.5 mm) under the cycloplegic condition, 7.53 ± 0.69 mm (5.7 mm-9.1 mm) under the scotopic condition, and 6.08 ± 1.14 mm (4.1 mm-8.8 mm) under the photopic condition. A statistically significant difference was noted in the pupil diameter between the cycloplegic and the scotopic condition (Z=-11.312, P=0.000) and between the photopic and the scotopic condition (t=24.403, P=0.000).

HIGHER-ORDER ABERRATIONS

Cycloplegic and scotopic conditions

Standard Zernike coefficients: Z₃^-3 (P=0.000), Z₄⁰ (P=0.000) and Z₅^-5 (P=0.006) increased statistically significantly under the cycloplegic condition (Table 1 and Figure 1).

 

 

 

 

Regarding Zernike coefficients of higher-order aberrations (Root mean square), there were significant differences in the total higher-order aberration (Z=-5.215, P=0.000), third-order aberration (Z=-11.341, P=0.000), fourth-order aberration (t=25.422, P=0.000), fifth-order aberration (Z=-11.440, P=0.000), sixth-order aberration (Z=-11.440, P=0.000), and spherical aberration (Z₄⁰ and Z₆⁰) (t=3.694, P=0.000). No statistically significant differences were noted in the coma aberration (including Z₃^-1, Z₃¹, Z₅^-1, and Z₅¹ ) (t=2.593, P=0.010) between two groups (Table 3).

 

 

 

 

Scotopic and photopic conditions

Standard Zernike coefficients: Z₄⁰ (P=0.000), Z₄² (P=0.009), Z₆^-4 (P=0.000), Z₆^-2 (P=0.003), and Z₆² (P=0.000) decreased statistically significantly under the photopic condition (Table 2 and Figure 1).

Regarding Zernike coefficients of higher-order aberrations (Root mean square), there were statistically significant differences in the total higher-order aberration (t=11.339, P=0.000), third-order aberration (t=9.782, P=0.000), fourth-order aberration (t=11.576, P=0.000), fifth-order aberration (Z=-6.253, P=0.000), sixth-order aberration (Z=-5.785, P=0.000), coma aberration (including Z₃^-1, Z₃¹, Z₅^-1, and Z₅¹) (Z=-8.490, P=0.000), and spherical aberration (Z₄⁰ and Z₆⁰) (Z=-8.503, P=0.000) (Table 3).

DOMINANT ABERRATIONS

There was a statistically significant difference in dominant aberrations between the cycloplegic and the scotopic condition (t=5.351, P=0.000), and between the scotopic and the photopic condition (Z=-8.806, P=0.000). RMS of dominant aberrations gradually decreased from cycloplegic, scotopic, to photopic conditions. The proportions of coma aberrations and trefoil aberrations were consistent with the three conditions. The proportion of vertical coma aberrations accounted for the most under the three conditions. The proportion of spherical aberrations decreased proportionally when the pupil size decreased (26% in the cycloplegic condition, 21% in the scotopic condition, and 16% in the photopic condition) (Figure 2).

 

 

DISCUSSION

Wavefront-guided customized ablation is a new technique in refractive surgery performed with the goal to obtain an aberration-free optical system for the eye⁽²⁰⁾. The surgeon designs the ablation protocol according to the diopter, corneal thickness, higher-order aberration and night pupil size.

PUPIL SIZE

The pupil diameter was 7.53 ± 0.69 mm under the scotopic condition, indicating that the wavefront aberration measurement under the scotopic condition can meet the requirement of the optical zone of 6.5 mm for the wavefront-guided surgery. The pupil diameter changes drastically in different conditions (P<0.010).

PHARMACOLOGICAL PUPIL DILATION AND SCOTOPIC CONDITION

Totally 15 men and 4 women, whose average age is 29 (range 19 to 56 years old), were examined using VISX WaveScan⁽⁷⁾. They found that the repeatability coefficient of higher-order aberrations was only 0.08 µm with limited deviation. In their study, after use of 1% Tropicamide Ophthalmic Solution USP (Bausch & Lomb, Rochester, New York), RMS of higher-order aberrations was 0.47 ± 01.7 µm; RMS of coma aberrations, 0.26 ± 0.15 µm; and RMS of spherical aberrations, 0.12 ± 0.21 µm. These findings were consistent with ours following pharmacological pupil dilation. In the current research, following pharmacological pupil dilation, the higher-order aberrations Z₃^-3 increased by 134%, and Z₄⁰ increased by 68% (P<0.010) (Figure 1). All the higher-order aberrations increased statistically significantly (P<0.010) excepting for coma aberrations (P=0.010). We found that the difference of higher-order aberrations was lower than 0.1 µm before and after pharmacological pupil dilation, though still with statistically significant difference. This can be explained in the following paragraph.

Firstly, the increase of the pupil diameter causes increase of higher-order aberrations. The NIDEK OPD-Scan was used for 102 eyes of 51 myopic patients⁽¹⁰⁾. When higher-order aberrations at the pupil size of 4 mm, 5 mm, and 6 mm were compared following use of 1% tropicamide, all higher-order aberrations increased unevenly as the pupil diameter increased, and the spherical aberrations were larger than the coma aberrations. This implies that there is a difference in higher-order aberrations for different pupil diameters even in the one time detecting procedure. This means that the higher-order aberrations increase with the pupil diameter for the same lenticular accommodation.

Secondly, pharmacological pupil dilation can cause uneven mydriasis and pupil centroid shift, leading to differences in higher-order aberrations^(3,16). Higher-order aberrations obtained by WaveScan in natural and pharmacological pupil dilation conditions were compared, and the results showed that pupil centroid shift >0.2 mm existed in 45% patients following pharmacological pupil dilation, causing damage to postoperative vision⁽⁹⁾.

Thirdly, the aberrations can be compensated by lenticular accommodation under physiological conditions⁽²¹⁾. Pharmacological pupil dilation reduces this compensation leading to increase of higherorder aberrations. Regarding the higherorder aberrations under scotopic condition using VISX WaveScan of patients before surgery, a group⁽¹³⁾ examined 532 eyes of 306 patients, whose average age is 41 ± 10 years (20 to 71 years), and another group⁽²⁾ examined 92 eyes of 51 patients, whose average age is 35 (23 to 58 years). The higherorder aberrations were extracted when the pupil diameter was 6 mm. Our results of Zernike coefficients and RMS of higher-order aberrations, coma aberrations, and spherical aberrations were consistent with those reported. In the dark environment, the pupil is naturally dilated and with natural lenticular accommodation the aberrations compensation from the lens is maintained as well to prevent the measurement error due to pharmacological pupil dilation⁽²²⁾. In this situation, higher-order aberrations were close to those got in the physiological status at night. Consequently, the measurement for natural eyes in the dark room is feasible for the refractive surgyery.

COMPARISON OF THE SCOTOPIC CONDITION AND THE PHOTOPIC CONDITION

When the scotopic condition was shifted to the photopic condition, the standard Zernike coefficients Z₄⁰, Z₄², Z₆^-4, Z₆^-2 and Z₆² decreased significantly (P<0.010). All higher-order aberrations decreased statistically significantly (P<0.010). Under both scotopic and photopic conditions, lenticular accommodation is maintained and this increases when the brightness changes. Changes to fourth-order and sixth-order aberrations after the accommodation were also reported^(23-24). Our research demonstrates that miotic accommodation apparently improves the vision quality. The WaveScan analyzes data reflected by the retina through the pupil using an objective technique, so the photo reception of photosensory cells determines the clear images⁽²⁵⁾. When the scotopic condition shifts to the photopic condition, iridis sphincter is contracted to decrease the pupil diameter, thus increasing sensitization of objects projected to the retinal cells, and keeping images clear on the retina. This also explains why clear vision is obtained through pinhole imaging and why miotics are used in clinical practice for patients with poor night vision. In this study, higher-order aberrations and other aberrations decreased apparently under the photopic condition, showing that increased lenticular accommodation and pupil contraction together helps to improve vision quality under the photopic condition.

DOMINANT ABERRATIONS

Under different conditions, the most common dominant aberrations included coma aberrations, trefoil aberrations and spherical aberrations, which is consistent with previously reported data^(26,27). In this study, the vertical coma aberrations accounted for about >30%, highest under all three conditions and no significant effect by pupil size variance, implying that the vertical coma aberrations appear the most frequent within the dominant aberrations. Additionally, the proportion of spherical aberrations decreases significantly when the pupil size decreases (Figure 2). The change of spherical aberrations and coma aberrations influence largely the third-order aberrations, and fourth-aberrations as well as the higher-order aberrations, as accepted by many researchers^(3,14,28-29). So, precise measurement of spherical aberration and coma before surgery plays an important role in vision recovery.

 

CONCLUSION

Different wavefront aberrations are closely correlated with the pupil size, so selection of appropriate wavefront measurement is essential for the wavefront-guided refractive surgery. The wavefront measurements under the scotopic condition with natural pupil by the WaveScan can meet the optical zone requirement of 6.5 mm for the wavefront-guided LASIK.

 

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Correspondence address:
Yao-yu Li
Department of Ophthalmology, General Hospital of Beijing - Command Area of PLA
Beijing 100.700, China
E-mail: [email protected]

Submitted for publication: November 27, 2011
Accepted for publication: February 3, 2012

 

 

Study was carried out at Department of Ophthalmology, General Hospital of Beijing, China.
Funding: No specific financial support was available for this study.
Disclosure of potential conflicts of interest: R.Fan, None; T.He, None; Y.Qiu, None; Y-L.Di, None; S.Xu, None, Y.Li, None.