Repeat selective laser trabeculoplasty in glaucoma and ocular hypertension: a review of efficacy and safety

Guilherme Barroso Guedes¹; Tiago Santos Prata^2,3; Matheus Pedrotti Chavez⁴; Augusto Paranhos Jr²

DOI: 10.5935/0004-2749.2025-0232

ABSTRACT

Repeat selective laser trabeculoplasty has emerged as a valuable option for managing intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension. This review synthesizes current evidence of the efficacy, safety, and clinical applicability of repeat selective laser trabeculoplasty. Evidence from randomized controlled trials, systematic reviews, and observational studies indicate that repeat selective laser trabeculoplasty effectively sustains significant intraocular pressure reduction with minimal complications. This procedure demonstrates comparable efficacy to that of initial selective laser trabeculoplasty, supporting its role as a sustainable, drop-free management strategy. However, further research is warranted to optimize treatment intervals, assess long-term outcomes, and evaluate cost-effectiveness across different healthcare settings.

Keywords: Glaucoma; Ocular hypertension; Intraocular pressure; Selective laser trabeculoplasty

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