Ectopia lentis refers to any condition in which the lens is displaced from its normal position. A subluxated lens is a partial displacement in which some zonules remain intact. A luxated or dislocated lens is the complete separation of all zonular attachments⁽¹⁾. Ectopia lentis is a secondary consequence of other conditions (e.g., trauma, large eye, tumors, cataracts, pseudoexfoliation syndrome) or it may be genetic in origin, with or without systemic components⁽¹⁾. Causes with systemic associations include Marfan syndrome, homocystinuria, Weill-Marchesani syndrome, Ehlers-Danlos syndrome, sulfite oxidase deficiency syndrome, and hyperlysinemia. Those without systemic associations include familial ectopia lentis, ectopia lentis et pupillae, and aniridia⁽²⁾. Signs and symptoms include refractive error, monocular diplopia, decreased best-corrected visual acuity, iridodonesis, cataracts, and displacement of the lens into the anterior chamber or vitreous. All these symptoms can progress in severity⁽¹⁾. Diagnosis requires a thorough evaluation, with wide dilatation of the pupil⁽²⁾. Surgery is usually central to treatment.

REFERENCES

1. Sadiq MA, Vanderveen D. Genetics of ectopia lentis. Semin Ophthalmol. 2013;28(5-6):313-20.

2. Nelson LB, Maumenee IH. Ectopia lentis. Surv Ophthalmol. 1982; 27(3):143-60.

Submitted for publication: September 17, 2024.
Accepted for publication: October 14, 2024.

Funding: This study received no specific financial support.

Disclosure of potential conflicts of interest: The authors declare no potential conflicts of interest.