Dear Editor,

We would like to share ideas on “TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population⁽¹⁾.” Tenório et al. concluded that “Our data suggest an association between TXNRD2 gene polymorphism (rs35934224) with primary open-angle glaucoma in an admixed Brazilian population⁽¹⁾. We agree TXNRD2 (rs35934224) CT genotype might be associated with primary open-angle glaucoma. The present report can give good data on genetic underlying background of glaucoma. In this study, Tenório et al. focused only a polymorphism.

Environmental confounding factors might be well controlled but there is a chance of effects of other genetic polymorphisms which are reported for association with primary open-angle glaucoma might still exist. Examples of those genetic polymorphisms are CDKN2B-AS1, GSTO1, GSTO2, GSTP1, GPX1OPA1, MFN1, and MFN2 polymorphisms^(2-4). Further studies on effects of other polymorphisms are very interesting.

REFERENCES

1. Tenório AL, Lira RPC, Carmo RFD, Galvão Filho RP, Falcão Neto PT, Vaz RT, et al. TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population. Arq Bras Oftalmol [Internet]. 2021[cited Dec 21]:S0004-27492021005005222. Available from: SciELO - Brasil - TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population

2. Sobot V, Stamenkovic M, Simic T, Jerotic D, Djokic M, Jaksic V, et al. Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. Exp Eye Res. 2021;214:108863.

3. Liu S, Chen S, Niu T. Genetic association between CDKN2B-AS1 polymorphisms and the susceptibility of primary open-angle glaucoma (POAG): a meta-analysis from 21,775 subjects. Ir J Med Sci. 2021. doi: 10.1007/s11845-021-02794-x. DOI: http://dx.doi.org/10.1007/s11845-021-02794-x

4. Milanowski P, Kosior-Jarecka E, Łukasik U, Wróbel-Dudzińska D, Milanowska J, Khor CC, et al. Associations between OPA1, MFN1, and MFN2 polymorphisms and primary open angle glaucoma in Polish participants of European ancestry. Ophthalmic Genet. 2021:1-6. doi: 10.1080/13816810.2021.1970197. DOI: http://dx.doi.org/10.1080/13816810.2021.1970197

Submitted for publication: December 13, 2021.
Accepted for publication: December 20, 2021.

Funding: This study received no specific financial support

Disclosure of potential conflicts of interest: None of the authors have any potential conflicts of interest to disclose